FREE Mirapex Coupon

Mirapex is a brand name for pramipexole dihydrochloride, a drug that’s also marketed as Mirapexin and Sifrol. It is thought to work by stimulating several types of dopamine receptors.

Indications and Off-Label Use

Mirapex has FDA approval for the treatment of early-stage Parkinson’s disease and restless legs syndrome. The drug is also used off-label to treat cluster headaches and to counteract the sexual dysfunction side effects that some patients experience with SSRIs (selective serotonin reuptake inhibitors). Mirapex has had promising results in treatment studies of bipolar disorder. The drug is also being studied for use in treating clinical depression and fibromyalgia.


Original Mirapex is offered in 0.125 mg, 0.25 mg, 0.5 mg, 1 mg, and 1.5 mg tablets.

Whereas original Mirapex might be taken several times per day, Mirapex ER is a once-a-day formula. Mirapex and Mirapex ER must not be taken simultaneously, but a change from one to the other can be made quickly under a doctor’s guidance.

Inactive ingredients in each tablet include colloidal silicon dioxide, corn starch, mannitol, magnesium stearate, and povidone.

Side Effects of Mirapex

Common side effects of Mirapex or pramipexole include:

• Headache
• Hyperalgesia (aches and pains)
• Muscle spasms
• Dizziness
• Nausea and vomiting
• Drowsiness
• Weakness
• Insomnia
• Decreased appetite
• Hallucinations
• Twitching and other unusual body movements
• Edema (swelling of the feet and ankles)

Rare side effects of the drug may include overeating, hypersexuality, excessive shopping, and compulsive gambling – even in patients who have never exhibited such behaviors before.

Some signs of a serious drug reaction include hives, respiratory trouble, and swelling of the mouth or face. Contact emergency medical personnel immediately if signs of a reaction occur. Contact a doctor to discuss altering the prescription if hallucinations, uneven heartbeats, or other serious side effects are experienced.

If you are taking Mirapex for restless legs syndrome but experience stronger symptoms of the disease, contact your doctor. Unless there are serious side effects, use of the drug should not be abruptly discontinued.


Because pramipexole may cause drowsiness and sudden sleep, users should not drive automobiles or otherwise use heavy machinery until they know how the drug affects them.

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